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KMID : 0608520060120010069
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Korean Journal of Oriental Medicine
2006 Volume.12 No. 1 p.69 ~ p.75
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Anticariogenic activity of acanthoic acid isolated form Acanthopanax koreanum NAKAI against oral pathogens
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Kim Hong-Jun
Jeong Seung-il
Lee Hwa-Jung
Ju Young-Seung
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Abstract
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This research was aimed to search for natural antimicrobial agents that are safe for humans and specific for oral pathogens. Acanthoic acid was isolated from the chloroform fraction of methanol extract of Acanthopanax koreanum NAKAI and its structure were elucidated by 13C-NMR, 1H-NMR and ESIMS. Antibacterial activity of acanthoic acid was investigated by the minimum inhibitory (MIC) and minimum bactericidal (MBC) concentration. MIC/MBC of acanthoic acid against Streptococcus mutans NAKAI causing dental caries was determined to be 2/4 ㎍/ mL, which was much lower than those of other natural antimicrobial agents such as 8/16 ㎍/mL of sanguinarine and 250/500 ㎍/mL of green tea extract, 500/500 ㎍/mL of thymol and borneol. Acanthoic acid also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus NAKAI and Streptococcus sanguis NAKAI, and Streptococcus gordonii NAKAI in the MIC range of 4~32 ㎍/mL. My finding suggests that acanthoic acid could be employed as a potential antibacterial agent for preventing dental caries.
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KEYWORD
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Acanthopanax koreanum NAKA, antimicrobial agents, acanthoic acid, minimum inhibitory(MIC)and minimum bactericidal(MBC)concentration
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